3/18/2023 0 Comments Scid beige mice![]() Rearing laboratory mice in groups is important since social isolation after weaning induces brain alterations, which entails behavioral abnormalities in adulthood. Therefore, the findings from this review may guide researchers to select the most appropriate immunodeficient strain, target gene, and animal species based on the research type, mutant gene effects, and similarity to human immunological features for stem cell research. More important, mice, rats, and other large animals exhibit very different immunological and physiological features in tissue and organs, including genetic background and a representation of human disease conditions. There have been numerous immunodeficient models developed by different gene defects, resulting in many different features in phenotype. In this review, we summarize various immunodeficient animal model systems with different target genes as valuable tools for biomedical research. Understanding the immunodeficient system can provide insights into the generation and use of immunodeficient animal models, presenting a unique system to explore the capabilities of the innate immune system. The event is largely dependent on the immune rejection of the recipient therefore, the immunogenic evaluation of candidate cells or tissues in immunodeficient animals is important. For the recovery or replacement of dysfunctional cells and tissue-the goal of stem cell research-successful engraftment of transplanted cells and tissues are essential events.
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